edoc

Community-associated Staphylococcus aureus from sub-saharan Africa and Germany : a cross-sectional geographic correlation study

Ruffing, Ulla and Alabi, Abraham and Kazimoto, Theckla and Vubil, Delfino C. and Akulenko, Ruslan and Abdulla, Salim and Alonso, Pedro and Bischoff, Markus and Germann, Anja and Grobusch, Martin P. and Helms, Volkhard and Hoffmann, Jonas and Kern, Winfried V. and Kremsner, Peter G. and Mandomando, Inacio and Mellmann, Alexander and Peters, Georg and Schaumburg, Frieder and Schubert, Sabine and Strauß, Lena and Tanner, Marcel and Briesen, Hagen von and Wende, Laura and Müller, Lutz von and Herrmann, Mathias. (2017) Community-associated Staphylococcus aureus from sub-saharan Africa and Germany : a cross-sectional geographic correlation study. Scientific Reports, 7 (1). p. 154.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/54665/

Downloads: Statistics Overview

Abstract

Clonal clusters and gene repertoires of Staphylococcus aureus are essential to understand disease and are well characterized in industrialized countries but poorly analysed in developing regions. The objective of this study was to compare the molecular-epidemiologic profiles of S. aureus isolates from Sub-Saharan Africa and Germany. S. aureus isolates from 600 staphylococcal carriers and 600 patients with community-associated staphylococcal disease were characterized by DNA hybridization, clonal complex (CC) attribution, and principal component (PCA)-based gene repertoire analysis. 73% of all CCs identified representing 77% of the isolates contained in these CCs were predominant in either African or German region. Significant differences between African versus German isolates were found for alleles encoding the accessory gene regulator type, enterotoxins, the Panton-Valentine leukocidin, immune evasion gene cluster, and adhesins. PCA in conjunction with silhouette analysis distinguished nine separable PCA clusters, with five clusters primarily comprising of African and two clusters of German isolates. Significant differences between S. aureus lineages in Africa and Germany may be a clue to explain the apparent difference in disease between tropical/(so-called) developing and temperate/industrialized regions. In low-resource countries further clinical-epidemiologic research is warranted not only for neglected tropical diseases but also for major bacterial infections.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Interventions (Lengeler)
UniBasel Contributors:Tanner, Marcel
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2045-2322
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Oct 2017 09:50
Deposited On:25 Apr 2017 11:56

Repository Staff Only: item control page