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Cyclosporin A, FK506 and rapamycin : more than just immunosuppression

Kunz, J. and Hall, M. N.. (1993) Cyclosporin A, FK506 and rapamycin : more than just immunosuppression. Trends in Biochemical Sciences, 18 (9). pp. 334-348.

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Official URL: http://edoc.unibas.ch/dok/A5262074

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Abstract

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall)
UniBasel Contributors:Hall, Michael N.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0968-0004
e-ISSN:0167-7640
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Nov 2017 10:00
Deposited On:22 Mar 2012 13:30

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