Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum

Kamena, F. and Spang, A.. (2004) Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science, 304 (5668). pp. 286-289.

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Official URL: http://edoc.unibas.ch/dok/A5259754

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Directionality in intracellular trafficking is essential to ensure the correct localization of proteins along the secretory pathway. Here, we found evidence for an active mechanism that prohibited back-fusion of de novo-generated vesicles with their donor compartment. Tip20p is a peripheral membrane protein implicated in consumption of COPI vesicles at the endoplasmic reticulum. However, a specific mutant of TIP20 did not interfere with COPII vesicle generation but allowed these vesicles to fuse back to the endoplasmic reticulum, a process that does not occur normally in the cell.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spang)
UniBasel Contributors:Spang, Anne
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 Nov 2017 15:31
Deposited On:22 Mar 2012 13:30

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