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An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe

Ruttens, David and Verleden, Stijn E. and Bijnens, Esmée M. and Winckelmans, Ellen and Gottlieb, Jens and Warnecke, Gregor and Meloni, Federica and Morosini, Monica and Van Der Bij, Wim and Verschuuren, Erik A. and Sommerwerck, Urte and Weinreich, Gerhard and Kamler, Markus and Roman, Antonio and Gomez-Olles, Susana and Berastegui, Cristina and Benden, Christian and Holm, Are Martin and Iversen, Martin and Schultz, Hans Henrik and Luijk, Bart and Oudijk, Erik-Jan and Kwakkel-van Erp, Johanna M. and Jaksch, Peter and Klepetko, Walter and Kneidinger, Nikolaus and Neurohr, Claus and Corris, Paul and Fisher, Andrew J. and Lordan, James and Meachery, Gerard and Piloni, Davide and Vandermeulen, Elly and Bellon, Hannelore and Hoffmann, Barbara and Vienneau, Danielle and Hoek, Gerard and de Hoogh, Kees and Nemery, Benoit and Verleden, Geert M. and Vos, Robin and Nawrot, Tim S. and Vanaudenaerde, Bart M.. (2017) An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe. The European respiratory journal, 49 (1). p. 1600484.

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Official URL: http://edoc.unibas.ch/54440/

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Abstract

Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.085- 1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Vienneau, Danielle and de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Sep 2018 14:12
Deposited On:24 Apr 2017 14:22

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