Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping

Studer, W. and Wu, X. and Siegemund, M. and Seeberger, M. and Filipovic, M.. (2006) Effects of dopexamine in a rat model of supracoeliac aortic cross-clamping and declamping. European Surgical Research, 38 (2). pp. 63-69.

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Official URL: http://edoc.unibas.ch/54306/

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This experimental study in rats was designed to demonstrate effects of dopexamine (3 microg kg(-1) min(-1), n = 6) or physiologic saline solution (n = 6) on systemic as well as regional perfusion during 30 min of supracoeliac aortic cross-clamping and during 180 min of reperfusion following declamping. Rats were surgically instrumented with arterial, right atrial and portal venous catheters, ultrasonic flow probes around the abdominal aorta, superior mesenteric and carotid artery, and a paediatric tonometer for intestinal mucosal PCO(2) measurement. During 120 min of reperfusion, fluid resuscitation was titrated to keep abdominal aortic blood flow above 80% of baseline values. We found that during cross-clamping, values of arterial lactate (p = 0.002) and intestinal tonometric PCO(2) (p = 0.018) were higher in the dopexamine group than in the control group.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesiologie (Steiner)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesiologie (Steiner)
UniBasel Contributors:Siegemund, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Karger Publishers
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Oct 2017 07:38
Deposited On:04 Oct 2017 08:05

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