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Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia

Boeck, Lucas and Graf, Rolf and Eggimann, Philippe and Pargger, Hans and Raptis, Dimitri A. and Smyrnios, Nicholas and Thakkar, Nehal and Siegemund, Martin and Rakic, Janko and Tamm, Michael and Stolz, Daiana. (2011) Pancreatic stone protein: a marker of organ failure and outcome in ventilator-associated pneumonia. Chest, 140 (4). pp. 925-932.

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Official URL: http://edoc.unibas.ch/54297/

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Abstract

Ventilator-associated pneumonia (VAP) is the most common hospital-acquired, life-threatening infection. Poor outcome and health-care costs of nosocomial pneumonia remain a global burden. Currently, physicians rely on their experience to discriminate patients with good and poor outcome. However, standardized prognostic measures might guide medical decisions in the future. Pancreatic stone protein (PSP)/regenerating protein (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill patients is unknown. The aim of this pilot study was to evaluate PSP/reg in VAP.; One hundred one patients with clinically diagnosed VAP were assessed. PSP/reg was retrospectively analyzed using deep-frozen serum samples from VAP onset up to day 7. The main end point was death within 28 days after VAP onset.; Serum PSP/reg was associated with the sequential organ failure assessment score from VAP onset (Spearman rank correlation coefficient 0.49 P > .001) up to day 7. PSP/reg levels at VAP onset were elevated in nonsurvivors (n = 20) as compared with survivors (117.0 ng/mL [36.1-295.3] vs 36.3 ng/mL [21.0-124.0] P = .011). The areas under the receiver operating characteristic curves of PSP/reg to predict mortality/survival were 0.69 at VAP onset and 0.76 at day 7. Two PSP/reg cutoffs potentially allow for identification of individuals with a particularly good and poor outcome. Whereas PSP/reg levels below 24 ng/mL at VAP onset were associated with a good chance of survival, levels above 177 ng/mL at day 7 were present in patients with a very poor outcome.; Serum PSP/reg is a biomarker related to organ failure and outcome in patients with VAP.; ISRCTN.org; No.: ISRCTN61015974; URL: www.isrctn.org.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesiologie (Steiner)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie > Anästhesiologie (Steiner)
UniBasel Contributors:Siegemund, Martin and Boeck, Lucas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0012-3692
e-ISSN:1931-3543
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Oct 2017 06:31
Deposited On:05 Oct 2017 06:28

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