Genetic Draft, Selective Interference, and Population Genetics of Rapid Adaptation

Neher, Richard A.. (2013) Genetic Draft, Selective Interference, and Population Genetics of Rapid Adaptation. Annual Review of Ecology, Evolution, and Systematics, 44. pp. 195-215.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/54020/

Downloads: Statistics Overview


To learn about the past from a sample of genomic sequences, one needs to understand how evolutionary processes shape genetic diversity. Most population genetics inferences are based on frameworks assuming that adaptive evolution is rare. But if positive selection operates on many loci simultaneously, as has recently been suggested for many species, including animals such as flies, then a different approach is necessary. In this review, I discuss recent progress in characterizing and understanding evolution in rapidly adapting populations, in which random associations of mutations with genetic backgrounds of different fitness, i.e., genetic draft, dominate over genetic drift. As a result, neutral genetic diversity depends weakly on population size but strongly on the rate of adaptation or more generally the variance in fitness. Coalescent processes with multiple mergers, rather than Kingman's coalescent, are appropriate genealogical models for rapidly adapting populations, with important implications for population genetics inference.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:Neher, Richard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Annual Reviews
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:01 Nov 2019 16:44
Deposited On:26 Jan 2018 14:21

Repository Staff Only: item control page