Intermediate phase in DNA melting

Neher, Richard A. and Gerland, Ulrich. (2006) Intermediate phase in DNA melting. Physical Review E, 73 (3). 030902.

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Official URL: http://edoc.unibas.ch/54007/

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We predict a temperature-driven phase transition of DNA below the melting transition. The additional, intermediate phase exists for repetitive sequences, when the two strands have different lengths. In this phase, the excess bases of the longer strand are completely absorbed as bulge loops inside the helical region. When the temperature is lowered, the excess bases desorb into overhanging ends, resulting in a contour length change. This continuous transition is in many aspects analogous to Bose-Einstein condensation. When the sequence is weakly disordered, the contour length changes discontinuously with temperature.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:Neher, Richard
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Sep 2019 07:27
Deposited On:27 Nov 2017 12:31

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