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EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length

Bühler, Marc and Steiner, Silvia and Mohn, Fabio and Paillusson, Alexandra and Mühlemann, Oliver. (2006) EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length. Nature structural & molecular biology, Vol. 13, no. 5. pp. 462-464.

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Official URL: http://edoc.unibas.ch/dok/A5251093

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Abstract

Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.
Faculties and Departments:09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Bühler, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ. Group
ISSN:1545-9993
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Jan 2016 07:46
Deposited On:22 Mar 2012 13:30

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