Manipulation of the Macrophage Response by Pathogenic Mycobacteria

Pieters, Jean. (2008) Manipulation of the Macrophage Response by Pathogenic Mycobacteria. In: Handbook of tuberculosis, [Vol. 1]: Molecular Biology and Biochemistry. Weinheim, pp. 91-117.

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The pathogenicity of Mycobacterium tuberculosis is to a large degree attributed to the capacity of these pathogens to survive within their host cells ‐ the macrophages. Mycobacteria do so by manipulating macrophage responses at multiple levels, both using host‐derived molecules as well as by expressing molecules that alter the normal fate of bacteria inside macrophages. This chapter focuses on several of the host as well as the mycobacterial mechanisms that are being manipulated to allow survival of pathogenic mycobacteria within macrophages. Mycobacterium tuberculosis is internalized by several receptors on phagocytes complement receptors the mannose receptor, CD14, scavenger receptors, and surfactant protein receptors all lead to the internalization of mycobacteria. Once internalized, pathogenic mycobacteria reside within phagosomes that initially cannot be distinguished from any other phagosome, that is formed, for example, through the ingestion of inert particles. Mycobacterium tuberculosis avoids lysosomal delivery and destruction inside macrophages through the hijacking of eukaryotic signal transduction mechanisms.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Biochemistry (Pieters)
UniBasel Contributors:Pieters, Jean
Item Type:Book Section, refereed
Book Section Subtype:Further Contribution in a Book
Note:Publication type according to Uni Basel Research Database: Book item
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Last Modified:25 Apr 2018 10:38
Deposited On:22 Mar 2012 13:30

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