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An Enantioselective Artificial Suzukiase Based on the Biotin–Streptavidin Technology

Chatterjee, Anamitra and Mallin, Hendrik and Klehr, Juliane and Vallapurackal, Jaicy and Finke, Aaron D. and Vera, Laura and Marsh, May and Ward, Thomas R.. (2016) An Enantioselective Artificial Suzukiase Based on the Biotin–Streptavidin Technology. Chemical Science, 7 (1). pp. 673-677.

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Abstract

Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee. The hybrid catalyst described herein shows comparable TOF to the previous aqueous-asymmetric Suzuki catalysts, and excellent stability under the reaction conditions to realize higher TON through longer reaction time.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Chatterjee, Anamitra and Mallin, Hendrik and Klehr, Juliane and Vallapurackal, Jaicy and Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:2041-6520
e-ISSN:2041-6539
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:25 Jan 2017 15:34
Deposited On:25 Jan 2017 15:34

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