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Capnocytophaga canimorsus : a human pathogen feeding at the surface of epithelial cells and phagocytes

Mally, M. and Shin, H. and Paroz, C. and Landmann, R. and Cornelis, G. R.. (2008) Capnocytophaga canimorsus : a human pathogen feeding at the surface of epithelial cells and phagocytes. PLoS Pathogens, Vol. 4, H. 9 , e1000164.

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Official URL: http://edoc.unibas.ch/dok/A5259131

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Abstract

Capnocytophaga canimorsus, a commensal bacterium of the canine oral flora, has been repeatedly isolated since 1976 from severe human infections transmitted by dog bites. Here, we show that C. canimorsus exhibits robust growth when it is in direct contact with mammalian cells, including phagocytes. This property was found to be dependent on a surface-exposed sialidase allowing C. canimorsus to utilize internal aminosugars of glycan chains from host cell glycoproteins. Although sialidase probably evolved to sustain commensalism, by releasing carbohydrates from mucosal surfaces, it also contributed to bacterial persistence in a murine infection model: the wild type, but not the sialidase-deficient mutant, grew and persisted, both when infected singly or in competition. This study reveals an example of pathogenic bacteria feeding on mammalian cells, including phagocytes by deglycosylation of host glycans, and it illustrates how the adaptation of a commensal to its ecological niche in the host, here the dog's oral cavity, contributes to being a potential pathogen.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Infection Biology (Landmann-Suter)
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Landmann-Suter, Regine and Cornelis, Guy R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
ISSN:1553-7366
e-ISSN:1553-7374
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Oct 2017 07:41
Deposited On:22 Mar 2012 13:29

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