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Upregulation of an Artificial Zymogen by Proteolysis

Liu, Zhe and Lebrun, Vincent and Kitanosono, Taku and Mallin, Hendrik and Köhler, Valentin and Häussinger, Daniel and Hilvert, Donald and Kobayashi, Shu and Ward, Thomas R.. (2016) Upregulation of an Artificial Zymogen by Proteolysis. Angewandte Chemie International Edition, 55 (38). pp. 11587-11590.

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Official URL: http://edoc.unibas.ch/53269/

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Abstract

Regulation of enzymatic activity is vital to living organisms. Here, we report the development and the genetic optimization of an artificial zymogen requiring the action of a natural protease to upregulate its latent asymmetric transfer hydrogenase activity.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger)
UniBasel Contributors:Ward, Thomas R. R. and Häussinger, Daniel and Liu, Zhe and Lebrun, Vincent and Mallin, Hendrik and Köhler, Valentin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1433-7851
e-ISSN:1521-3773
Note:Publication type according to Uni Basel Research Database: Journal article -- The final publication is available at Wiley, see DOI link
Language:English
Identification Number:
Last Modified:17 Aug 2018 12:38
Deposited On:25 Jan 2017 14:28

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