A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue

Scherberich, Arnaud and Di Maggio, Nunzia Di and McNagny, Kelly M.. (2013) A familiar stranger: CD34 expression and putative functions in SVF cells of adipose tissue. World journal of stem cells, 5 (1). pp. 1-8.

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Official URL: http://edoc.unibas.ch/53099/

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Human adipose tissue obtained by liposuction is easily accessible and an abundant potential source of autologous cells for regenerative medicine applications. After digestion of the tissue and removal of differentiated adipocytes, the so-called stromal vascular fraction (SVF) of adipose, a mix of various cell types, is obtained. SVF contains mesenchymal fibroblastic cells, able to adhere to culture plastic and to generate large colonies in vitro, that closely resemble bone marrow-derived colony forming units-fibroblastic, and whose expanded progeny, adipose mesenchymal stem/stromal cells (ASC), show strong similarities with bone marrow mesenchymal stem cells. The sialomucin CD34, which is well known as a hematopoietic stem cell marker, is also expressed by ASC in native adipose tissue but its expression is gradually lost upon standard ASC expansion in vitro. Surprisingly little is known about the functional role of CD34 in the biology and tissue forming capacity of SVF cells and ASC. The present editorial provides a short introduction to the CD34 family of sialomucins and reviews the data from the literature concerning expression and function of these proteins in SVF cells and their in vitro expanded progeny.
Faculties and Departments:03 Faculty of Medicine
UniBasel Contributors:Scherberich, Arnaud
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Oct 2017 08:16
Deposited On:03 Oct 2017 08:16

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