Engineered decellularized matrices to instruct bone regeneration processes

Papadimitropoulos, Adam and Scotti, Celeste and Bourgine, Paul and Scherberich, Arnaud and Martin, Ivan. (2015) Engineered decellularized matrices to instruct bone regeneration processes. Bone, 70. pp. 66-72.

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Official URL: http://edoc.unibas.ch/53086/

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Despite the significant progress in the field of bone tissue engineering, cell-based products have not yet reached the stage of clinical adoption. This is due to the uncertain advantages from the standard-of-care, combined with challenging cost-and regulatory-related issues. Novel therapeutic approaches could be based on exploitation of the intrinsic regenerative capacity of bone tissue, provided the development of a deeper understanding of its healing mechanisms. While it is well-established that endogenous progenitors can be activated toward bone formation by overdoses of single morphogens, the challenge to stimulate the healing processes by coordinated and controlled stimulation of specific cell populations remains open. Here, we review the recent approaches to generate osteoinductive materials based on the use of decellularized extracellular matrices (ECM) as reservoirs of multiple factors presented at physiological doses and through the appropriate ligands. We then propose the generation of customized engineered and decellularized ECM (i) as a tool to better understand the processes of bone regeneration and (ii) as safe and effective "off-the-shelf" bone grafts for clinical use. This article is part of a Special Issue entitled Stem Cells and Bone.
Faculties and Departments:03 Faculty of Medicine
UniBasel Contributors:Scherberich, Arnaud
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Oct 2017 09:38
Deposited On:06 Oct 2017 09:38

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