edoc

Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers

Mondadori, Christian R. A. and de Quervain, Dominique J.-F. and Buchmann, Andreas and Mustovic, Henrietta and Wollmer, M. Axel and Schmidt, Conny F. and Boesiger, Peter and Hock, Christoph and Nitsch, Roger M. and Papassotiropoulos, Andreas and Henke, Katharina. (2007) Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers. Cerebral cortex, Vol. 17, H. 8. pp. 1934-1947.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5257160

Downloads: Statistics Overview

Abstract

The apolipoprotein E (APOE) epsilon4 allele is the major genetic risk factor for Alzheimer's disease, but an APOE effect on memory performance and memory-related neurophysiology in young, healthy subjects is unknown. We found an association of APOE epsilon4 with better episodic memory compared with APOE epsilon2 and epsilon3 in 340 young, healthy persons. Neuroimaging was performed in a subset of 34 memory-matched individuals to study genetic effects on memory-related brain activity independently of differential performance. E4 carriers decreased brain activity over 3 learning runs, whereas epsilon2 and epsilon3 carriers increased activity. This smaller neural investment of epsilon4 carriers into learning reappeared during retrieval: epsilon4 carriers exhibited reduced retrieval-related activity with equal retrieval performance. APOE isoforms had no differential effects on cognitive measures other than memory, brain volumes, and brain activity related to working memory. We suggest that APOE epsilon4 is associated with good episodic memory and an economic use of memory-related neural resources in young, healthy humans.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Papassotiropoulos, Andreas and de Quervain, Dominique J.-F.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Oxford University Press
ISSN:1047-3211
e-ISSN:1460-2199
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:28 Nov 2017 07:40
Deposited On:22 Mar 2012 13:29

Repository Staff Only: item control page