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A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites

Thamm, Irene and Richers, Johannes and Rychlik, Michael and Tiefenbacher, Konrad. (2016) A six-step total synthesis of α-thujone and d6-α-thujone, enabling facile access to isotopically labelled metabolites. Chemical Communications, 52 (78). pp. 11701-11703.

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Official URL: http://edoc.unibas.ch/52651/

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Abstract

The short synthesis of alpha-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d(6)-acetone can be used as a starting material, the route developed allows for the facile incorporation of isotopic labels which are required for detecting and quantifying trace amounts via GC/MS analysis.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Organische Chemie (Sparr)
05 Faculty of Science > Departement Chemie > Chemie > Synthesis of Functional Modules (Tiefenbacher)
UniBasel Contributors:Tiefenbacher, Konrad Karl
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1359-7345
e-ISSN:1364-548X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Jun 2017 09:26
Deposited On:14 Jun 2017 09:26

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