Percolation theory and the role of maize starch as a disintegrant for a low water-soluble drug

Kimura, Go and Puchkov, Maxim and Betz, Gabriele and Leuenberger, Hans. (2007) Percolation theory and the role of maize starch as a disintegrant for a low water-soluble drug. Pharmaceutical development and technology, Vol. 12, H. 1. pp. 11-19.

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Official URL: http://edoc.unibas.ch/dok/A5248992

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The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited to the study of binary systems. In this work it is shown how it can be used to analyze the behavior of binary and ternary systems for caffeine and mefenamic acid formulations containing a starch-based disintegrant. The percolation threshold p, can be described by the volumetric ratio of the disintegrant to the drug substance being equal to p(c) = 0.2 (v/v) in in which both components have similar average particle sizes. In addition, the behavior of the disintegration time in the neighborhood of the percolation threshold can be mathematically modeled with the basic equation of the percolation theory yielding a critical exponent q = 0.28 +/- 0.06.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Ehemalige Einheiten Pharmazie > Industrial Pharmacy Lab (Betz)
UniBasel Contributors:Betz, Gabriele and Kimura, Go and Puchkov, Maxim
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Marcel Dekker
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:22
Deposited On:22 Mar 2012 13:29

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