edoc

Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome

Urwyler, Sandrine Andrea and Timper, Katharina and Fenske, Wiebke and de Mota, Nadia and Blanchard, Anne and Kühn, Felix and Frech, Nica and Arici, Birsen and Rutishauser, Jonas and Kopp, Peter and Stettler, Christoph and Müller, Beat and Katan, Mira and Llorens-Cortes, Catherine and Christ-Crain, Mirjam. (2016) Plasma Apelin Concentrations in Patients With Polyuria-Polydipsia Syndrome. The Journal of Clinical Endocrinology and Metabolism, 101 (5). pp. 1917-1923.

[img] PDF - Published Version
Restricted to Repository staff only until 1 January 2020.

127Kb

Official URL: http://edoc.unibas.ch/52459/

Downloads: Statistics Overview

Abstract

Apelin and arginine vasopressin are antagonists in the regulation of body fluid and osmotic homeostasis. There are no data about apelin levels in patients with polyuria-polydipsia syndrome (PPS).; To investigate plasma apelin levels and plasma apelin to copeptin ratios in patients with PPS and healthy volunteers using copeptin as a surrogate marker for arginine vasopressin.; We included 41 patients with PPS in this post hoc analysis of a prospective study performed in tertiary care hospitals in Switzerland and Germany and 113 healthy volunteers as a control group.; Plasma apelin and copeptin levels were measured in 15 patients with complete central diabetes insipidus (DI), seven patients with complete nephrogenic DI, 19 patients with primary polydipsia (PP), and 113 healthy volunteers.; Plasma apelin levels were highest in patients with complete nephrogenic DI (413 pmol/L; interquartile range, 332-504 pmol/L; P = .01) and lower in patients with PP (190 [172-215] pmol/L; P .9) was similar to healthy volunteers (57 [37-102] pmol/pmol). In contrast, the apelin to copeptin ratio was higher in patients with complete central DI (89 [73-135] pmol/pmol; P = .02) and lower in patients with complete nephrogenic DI (7 [6-10] pmol/pmol; P > .001) compared to healthy volunteers.; In PP, normal plasma apelin to copeptin ratio attests a normal water homeostasis. In contrast, in patients with central or nephrogenic DI, the increased or decreased apelin to copeptin ratio, respectively, reflects a disturbed osmotic and body fluid homeostasis.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie > Endokrinologie (Christ-Crain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie > Endokrinologie (Christ-Crain)
UniBasel Contributors:Christ-Crain, Mirjam and Müller, Beat
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:0021-972X
e-ISSN:1945-7197
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:05 Dec 2017 10:55
Deposited On:05 Oct 2017 07:28

Repository Staff Only: item control page