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Statin use and risk of glioma: population-based case–control analysis

Seliger, Corinna and Meier, Christoph Rudolf and Becker, Claudia and Jick, Susan Sara and Bogdahn, Ulrich and Hau, Peter and Leitzmann, Michael Fred. (2016) Statin use and risk of glioma: population-based case–control analysis. European Journal of Epidemiology, 31 (9). pp. 947-952.

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Official URL: http://edoc.unibas.ch/52430/

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Abstract

Statins have been reported to decrease the incidence of cancer, but the risk of glioma among statin users has been investigated in only two prior observational studies, both of them suggesting a modest protective effect of statins. We conducted a matched case-control study using data from the UK-based Clinical Practice Research Datalink to analyse use of statins among 2469 cases with glioma and 24,690 controls. We performed conditional logistic regression analysis to calculate relative risks, estimated as odds ratios (ORs) with 95 % confidence intervals (CIs) adjusting for multiple confounding factors. As compared with non-use of statins, use of statins was not associated with risk of glioma (OR for ≥90 prescriptions=0.75; 95 % CI 0.48-1.17). Our findings do not support previous sparse evidence of a possible inverse association between statin use and glioma risk.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Klinische Pharmazie/Spitalpharmazie (Meier)
UniBasel Contributors:Meier, Christoph R.
Item Type:Article, refereed
Article Subtype:Book Review
Publisher:Springer Science+Business Media B.V.
ISSN:1573-7284
e-ISSN:1573-7284
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:05 Mar 2019 18:34
Deposited On:05 Mar 2019 18:34

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