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Self-Assembly of Amphiphilic Block Copolypeptoids - Micelles, Worms and Polymersomes

Fetsch, Corinna and Gaitzsch, Jens and Messager, Lea and Battaglia, Giuseppe and Luxenhofer, Robert. (2016) Self-Assembly of Amphiphilic Block Copolypeptoids - Micelles, Worms and Polymersomes. Scientific Reports, 6. p. 33491.

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Abstract

Polypeptoids are an old but recently rediscovered polymer class with interesting synthetic, physicochemical and biological characteristics. Here, we introduce new aromatic monomers, N-benzyl glycine N-carboxyanhydride and N-phenethyl glycine N-carboxyanhydride and their block copolymers with the hydrophilic polysarcosine. We compare their self-assembly in water and aqueous buffer with the self-assembly of amphiphilic block copolypeptoids with aliphatic side chains. The aggregates in water were investigated by dynamic light scattering and electron microscopy. We found a variety of morphologies, which were influenced by the polymer structure as well as by the preparation method. Overall, we found polymersomes, worm-like micelles and oligo-lamellar morphologies as well as some less defined aggregates of interconnected worms and vesicles. Such, this contribution may serve as a starting point for a more detailed investigation of the self-assembly behavior of the rich class of polypeptoids and for a better understanding between the differences in the aggregation behavior of non-uniform polypeptoids and uniform peptoids.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2045-2322
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:12 Oct 2017 09:49
Deposited On:23 Jan 2017 14:48

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