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Engineering and Assembly of Protein Modules into Functional Molecular Systems

Hirschi, Stephan and Stauffer, Mirko and Harder, Daniel and Mueller, Daniel J. and Meier, Wolfgang and Fotiadis, Dimitrios. (2016) Engineering and Assembly of Protein Modules into Functional Molecular Systems. Chimia, 70 (6). pp. 398-401.

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Official URL: http://edoc.unibas.ch/51777/

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Abstract

Synthetic biology approaches range from the introduction of unique features into organisms to the assembly of isolated biomacromolecules or synthetic building blocks into artificial biological systems with biomimetic or completely novel functionalities. Simple molecular systems can be based on containers on the nanoscale that are equipped with tailored functional modules for various applications in healthcare, industry or biological and medical research. The concept, or vision, of assembling native or engineered proteins and/or synthetic components as functional modules into molecular systems is discussed. The main focus is laid on the engineering of energizing modules generating chemical energy, transport modules using this energy to translocate molecules between compartments of a molecular system, and catalytic modules (bio-) chemically processing the molecules. Further key aspects of this discourse are possible approaches for the assembly of simple nanofactories and their applications in biotechnology and medical health.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Schweizerische Chemische Gesellschaft
ISSN:0009-4293
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:11 Jan 2017 14:00
Deposited On:09 Jan 2017 15:01

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