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Salivary and hair glucocorticoids and sleep in very preterm children during school age

Maurer, Natalie and Perkinson-Gloor, Nadine and Stalder, Tobias and Hagmann-von Arx, Priska and Brand, Serge and Holsboer-Trachsler, Edith and Wellmann, Sven and Grob, Alexander and Weber, Peter and Lemola, Sakari. (2016) Salivary and hair glucocorticoids and sleep in very preterm children during school age. Psychoneuroendocrinology. pp. 166-174.

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Abstract

Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7–12 years were recruited for the present study. To assess HPA axis activity, salivary cortisol was measured at awakening, 10, 20, and 30 min later. In addition, hair cortisol and cortisone concentrations were quantified using liquid chromatography tandem mass spectrometry to assess cumulative endocrine activity over the preceding months. One night of in-home polysomnographic sleep assessment was conducted to assess sleep duration, sleep continuity, and sleep architecture. Children born very preterm showed significantly lower levels of cortisol at awakening and lower overall post-awakening cortisol secretion, lower cortisone in hair, and earlier sleep onset than full-term children. Across the whole sample, overall post-awakening cortisol secretion was positively related to sleep onset time and negatively to sleep duration. The association between prematurity status and post-awakening cortisol secretion was partially mediated by earlier sleep onset time. In conclusion, this study provides evidence for a possible down-regulation of the HPA axis activity and slightly earlier sleep phase in very preterm children during school age.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Persönlichkeits- und Entwicklungspsychologie > Entwicklungs- und Persönlichkeitspsychologie (Grob)
UniBasel Contributors:Maurer, Natalie and Hagmann-von Arx, Priska and Lemola, Sakari and Grob, Alexander and Perkinson-Gloor, Nadine
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0306-4530
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:20 Jul 2017 06:12
Deposited On:06 Jul 2017 10:01

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