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GABA neurons of the VTA drive conditioned place aversion

Tan, Kelly R. and Yvon, Cédric and Turiault, Marc and Mirzabekov, Julie J. and Doehner, Jana and Labouèbe, Gwenaël and Deisseroth, Karl and Tye, Kay M. and Lüscher, Christian. (2012) GABA neurons of the VTA drive conditioned place aversion. Neuron, 73 (6). pp. 1173-1183.

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Official URL: http://edoc.unibas.ch/50647/

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Abstract

Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Physiopathology of basal ganglia neuronal subcircuits (Tan)
UniBasel Contributors:Tan, Kelly
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0896-6273
e-ISSN:1097-4199
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Nov 2017 11:26
Deposited On:30 Nov 2017 11:26

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