Brain micro-ecologies: neural stem cell niches in the adult mammalian brain

Riquelme, Patricio A. and Drapeau, Elodie and Doetsch, Fiona. (2008) Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. Philosophical Transactions B: Biological Sciences, 363 (1489). pp. 123-137.

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Official URL: http://edoc.unibas.ch/50361/

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Neurogenesis persists in two germinal regions in the adult mammalian brain, the subventricular zone of the lateral ventricles and the subgranular zone in the hippocampal formation. Within these two neurogenic niches, specialized astrocytes are neural stem cells, capable of self-renewing and generating neurons and glia. Cues within the niche, from cell-cell interactions to diffusible factors, are spatially and temporally coordinated to regulate proliferation and neurogenesis, ultimately affecting stem cell fate choices. Here, we review the components of adult neural stem cell niches and how they act to regulate neurogenesis in these regions.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:The Royal Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 10:24
Deposited On:28 Nov 2017 10:24

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