A specialized vascular niche for adult neural stem cells

Tavazoie, Masoud and Van der Veken, Lieven and Silva-Vargas, Violeta and Louissaint, Marjorie and Colonna, Lucrezia and Zaidi, Bushra and Garcia-Verdugo, Jose Manuel and Doetsch, Fiona. (2008) A specialized vascular niche for adult neural stem cells. Cell Stem Cell, 3 (3). pp. 279-288.

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Official URL: http://edoc.unibas.ch/50351/

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Stem cells reside in specialized niches that regulate their self-renewal and differentiation. The vasculature is emerging as an important component of stem cell niches. Here, we show that the adult subventricular zone (SVZ) neural stem cell niche contains an extensive planar vascular plexus that has specialized properties. Dividing stem cells and their transit-amplifying progeny are tightly apposed to SVZ blood vessels both during homeostasis and regeneration. They frequently contact the vasculature at sites that lack astrocyte endfeet and pericyte coverage, a modification of the blood-brain barrier unique to the SVZ. Moreover, regeneration often occurs at these sites. Finally, we find that circulating small molecules in the blood enter the SVZ. Thus, the vasculature is a key component of the adult SVZ neural stem cell niche, with SVZ stem cells and transit-amplifying cells uniquely poised to receive spatial cues and regulatory signals from diverse elements of the vascular system.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 09:25
Deposited On:28 Nov 2017 09:25

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