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Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging

Silva-Vargas, Violeta and Crouch, Elizabeth E. and Doetsch, Fiona. (2013) Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Current Opinion in Neurobiology, 23 (6). pp. 935-942.

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Official URL: http://edoc.unibas.ch/50349/

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Abstract

Stem cells persist in specialized niches in the adult mammalian brain. Emerging findings highlight the complexity and heterogeneity of different compartments in the niche, as well as the presence of local signaling microdomains. Stem cell quiescence and activation are regulated not only by anchorage to the niche and diffusible signals, but also by biophysical properties, including fluid dynamics. Importantly, the adult neural stem cell niche integrates both local and systemic changes, reflecting the physiological state of the organism. Moreover niche signaling is bidirectional, with stem cells and their progeny and niche cells dynamically interacting with each other during homeostasis, regeneration and aging.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Stem Cell Biology (Doetsch)
UniBasel Contributors:Doetsch, Fiona
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0959-4388
e-ISSN:1873-6882
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Nov 2017 12:28
Deposited On:30 Nov 2017 12:28

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