edoc

Gene therapy works in animal models of rheumatoid arthritis...so what!

van de Loo, F. A. and Geurts, J. and van den Berg, W. B.. (2006) Gene therapy works in animal models of rheumatoid arthritis...so what! Current Rheumatology Reports, 8 (5). pp. 386-393.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/50006/

Downloads: Statistics Overview

Abstract

Rheumatoid arthritis (RA) is a systemic disease with polyarticular manifestation of chronic inflammation in the knees and small joints of hand and feet. The current systemic anti-tumor necrosis factor (TNF)-alpha therapies with biologics ameliorate disease in 60% to 70% of RA patients. However, biologics must be given systemically in relatively high dosages to achieve constant therapeutic levels in the joints, and side effects have been reported. To this end, local gene delivery can provide an alternative approach to achieve high, long-term expression of biologics, optimizing the therapeutic efficacy and minimizing systemic exposure. Evidence from animal models convincingly supports the application of local gene therapy in rheumatoid arthritis, but preclinical studies remain necessary to evaluate the merge of cell-specific targeting, viral vector development, and disease-regulated transgene expression to optimize efficacy and safety.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Ehemalige Einheiten Operative Fächer (Klinik) > Orthopädie (Valderrabano)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Ehemalige Einheiten Operative Fächer (Klinik) > Orthopädie (Valderrabano)
UniBasel Contributors:Geurts, Jeroen
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Current Medicine Group
ISSN:1523-3774
e-ISSN:1534-6307
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Nov 2017 10:47
Deposited On:27 Nov 2017 10:47

Repository Staff Only: item control page