The protooncogene Ski controls Schwann cell proliferation and myelination

Atanasoski, Suzana and Notterpek, Lucia and Lee, Hye-Youn and Castagner, François and Young, Peter and Ehrengruber, Markus U. and Meijer, Dies and Sommer, Lukas and Stavnezer, Ed and Colmenares, Clemencia and Suter, Ueli. (2004) The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron, 43 (4). pp. 499-511.

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Official URL: http://edoc.unibas.ch/49924/

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Schwann cell proliferation and subsequent differentiation to nonmyelinating and myelinating cells are closely linked processes. Elucidating the molecular mechanisms that control these events is key to the understanding of nerve development, regeneration, nerve-sheath tumors, and neuropathies. We define the protooncogene Ski, an inhibitor of TGF-beta signaling, as an essential component of the machinery that controls Schwann cell proliferation and myelination. Functional Ski overexpression inhibits TGF-beta-mediated proliferation and prevents growth-arrested Schwann cells from reentering the cell cycle. Consistent with these findings, myelinating Schwann cells upregulate Ski during development and remyelination after injury. Myelination is blocked in myelin-competent cultures derived from Ski-deficient animals, and genes encoding myelin components are downregulated in Ski-deficient nerves. Conversely, overexpression of Ski in Schwann cells causes an upregulation of myelin-related genes. The myelination-regulating transcription factor Oct6 is involved in a complex modulatory relationship with Ski. We conclude that Ski is a crucial signal in Schwann cell development and myelination.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Cellular Neurobiology (Atanasoski)
UniBasel Contributors:Atanasoski, Suzana
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 15:05
Deposited On:04 Oct 2017 15:05

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