Neuropeptide S Receptor Gene-Converging Evidence for a Role in Panic Disorder

Domschke, K. and Reif, A. and Weber, H. and Richter, J. and Hohoff, C. and Ohrmann, P. and Pedersen, A. and Bauer, J. and Suslow, T. and Kugel, H. and Heindel, W. and Baumann, C. and Klauke, B. and Jacob, C. and Maier, W. and Fritze, J. and Bandelow, B. and Krakowitzky, P. and Rothermundt, M. and Erhardt, A. and Binder, E. and Holsboer, F. and Gerlach, A. L. and Kircher, T. and Lang, T. and Alpers, G. W. and Ströhle, A. and Fehm, L. and Gloster, A. T. and Wittchen, H. -U. and Arolt, V. and Pauli, P. and Hamm, A. and Deckert, J.. (2010) Neuropeptide S Receptor Gene-Converging Evidence for a Role in Panic Disorder. Molecular Psychiatry, 16 (9). pp. 938-948.

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Animal studies have suggested neuropeptide S (NPS) and its receptor (NPSR) to be involved in the pathogenesis of anxiety-related behavior. In this study, a multilevel approach was applied to further elucidate the role of NPS in the etiology of human anxiety. The functional NPSR A/T (Asn¹⁰⁷Ile) variant (rs324981) was investigated for association with (1) panic disorder with and without agoraphobia in two large, independent case-control studies, (2) dimensional anxiety traits, (3) autonomic arousal level during a behavioral avoidance test and (4) brain activation correlates of anxiety-related emotional processing in panic disorder. The more active NPSR rs324981 T allele was found to be associated with panic disorder in the female subgroup of patients in both samples as well as in a meta-analytic approach. The T risk allele was further related to elevated anxiety sensitivity, increased heart rate and higher symptom reports during a behavioral avoidance test as well as decreased activity in the dorsolateral prefrontal, lateral orbitofrontal and anterior cingulate cortex during processing of fearful faces in patients with panic disorder. The present results provide converging evidence for a female-dominant role of NPSR gene variation in panic disorder potentially through heightened autonomic arousal and distorted processing of anxiety-relevant emotional stimuli.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Health & Intervention > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Gloster, Andrew
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:15 Jan 2018 10:39
Deposited On:15 Jan 2018 10:39

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