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Noncanonical inflammasomes: caspase-11 activation and effector mechanisms

Broz, Petr and Monack, Denise M.. (2013) Noncanonical inflammasomes: caspase-11 activation and effector mechanisms. PLoS Pathogens, 9 (2). e1003144.

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Abstract

Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1. Recently, a new noncanonical inflammasome pathway has been described that activates caspase-11, an understudied pro-inflammatory caspase. Despite new insights into the signaling events that control caspase-11 activation, a number of unanswered questions remain...
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Infection Biology (Broz)
UniBasel Contributors:Broz, Petr
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Public Library of Science
ISSN:1553-7366
e-ISSN:1553-7374
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:13 Oct 2017 07:49
Deposited On:27 Apr 2017 06:26

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