Study of Ca2+, Mn2+and Cu2+ binding to DNA in solution by means of IR spectroscopy

Hackl, E. V. and Kornilova, S. V. and Kapinos, L. E. and Andrushchenko, V. V. and Galkin, V. L. and Grigoriev, D. N. and Blagoi, Y. P.. (1997) Study of Ca2+, Mn2+and Cu2+ binding to DNA in solution by means of IR spectroscopy. Journal of Molecular Structure , 408. pp. 229-232.

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The interaction of Cu2+, Mn2+ and Ca2+ ions with the DNA macromolecule was studied in aqueous solutions at different metal ion concentrations. All these ions interact with both the bases and the phosphate groups of DNA. Cu2+ ions alter the DNA B-conformation at [Cu2+] > 2 × 10−2M. Metal ions binding to DNA induce DNA compactisation. The highly positive cooperativity of this process was shown. The binding constants and parameters of cooperativity of the metal ions binding to DNA were estimated.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nanobiology Argovia (Lim)
UniBasel Contributors:Kapinos Schneider, Larisa E. E
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Nov 2017 11:13
Deposited On:22 Nov 2017 11:13

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