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New perspectives into bacterial DNA transfer to human cells

Llosa, M. and Schröder, G. and Dehio, C.. (2012) New perspectives into bacterial DNA transfer to human cells. Trends in Microbiology, 20 (8). pp. 355-359.

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Official URL: http://edoc.unibas.ch/48078/

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Abstract

The type IV secretion system (T4SS) VirB/D4 of the facultative intracellular pathogen Bartonella henselae is known to translocate bacterial effector proteins into human cells. Two recent reports on DNA transfer into human cells have demonstrated the versatility of this bacterial secretion system for macromolecular substrate transfer. Moreover, these findings have opened the possibility for developing new tools for DNA delivery into specific human cell types. DNA can be introduced into these cells covalently attached to a site-specific integrase with potential target sequences in the human genome. This novel DNA delivery system is discussed in the context of existing methods for genetic modification of human cells.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Dehio)
UniBasel Contributors:Dehio, Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0966-842X
e-ISSN:1878-4380
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Nov 2017 10:44
Deposited On:30 Nov 2017 10:44

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