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In vivo activity of next generation synthetic ozonides against Schistosoma species

Keiser, J. and Ingram, K. and Vargas, M. and Chollet, J. and Wang, X. and Dong, Y. and Vennerstrom, J. L.. (2011) In vivo activity of next generation synthetic ozonides against Schistosoma species. Antimicrobial agents and chemotherapy, 56 (2). pp. 1090-1092.

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Official URL: http://edoc.unibas.ch/47147/

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Abstract

We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni with total and female worm burden reductions of 80 and 90% (p < 0.05). Furthermore, treatment of S. haematobium infected mice with OZ418 reduced total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Society for Microbiology
ISSN:0066-4804
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:23 Mar 2017 15:12
Deposited On:23 Mar 2017 15:12

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