Novel real-time PCR for the universal detection of Strongyloides species

Kramme, Stefanie and Nissen, Nicole and Soblik, Hanns and Erttmann, Klaus and Tannich, Egbert and Fleischer, Bernhard and Panning, Marcus and Brattig, Norbert. (2011) Novel real-time PCR for the universal detection of Strongyloides species. Journal of medical microbiology, 60 (Pt 4). pp. 454-458.

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Official URL: http://edoc.unibas.ch/46989/

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Strongyloidiasis is a neglected disease that is prevalent mainly in tropical and subtropical regions. It is caused by intestinal nematodes of the genus Strongyloides. Due to the rise in worldwide travel, infections are increasingly encountered in non-endemic regions. Diagnosis is hampered by insensitive and laborious detection methods. A universal Strongyloides species real-time PCR was developed with an internal competitive control system. The 95% limit of detection as determined by probit analysis was one larva per PCR equivalent to 100 larvae per 200 mg stool. The assay proved to be 100% specific as assessed using a panel of parasites and bacteria and thus might be useful in the diagnostic setting as well as for Strongyloides research.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Kramme, Stefanie
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Jul 2018 12:04
Deposited On:16 Jul 2018 12:04

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