Somatization in major depression--clinical features and genetic associations

Klengel, T. and Heck, A. and Pfister, H. and Brückl, T. and Hennings, J. M. and Menke, A. and Czamara, D. and Müller-Myhsok, B. and Ising, M.. (2011) Somatization in major depression--clinical features and genetic associations. Acta Psychiatrica Scandinavica, 124 (4). pp. 317-328.

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Official URL: http://edoc.unibas.ch/46942/

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To identify clinical variables and genetic variations within monoaminergic genes known to be implicated in pain perception that are associated with the occurrence of somatization symptoms in patients with major depression.; Somatization was evaluated using the respective subscale of the Symptom Checklist SCL-90-R. Six monoaminergic genes were identified showing an involvement in pain perception and somatization according to the literature: COMT, HTR2A, SLC6A2, SLC6A4, DRD4, and TPH1. One hundred and eighteen single nucleotide polymorphisms (SNPs) within these genes were genotyped using Illumina BeadChips in a sample of 398 at least moderately to severely depressed in-patients participating in the Munich Antidepressant Response Signature (MARS) project.; Thirty SNPs exhibit nominally significant associations with somatization. One SNP (rs9534505) located in intron 2 of the HTR2A gene withstood correction for multiple testing. Clinical data provide further evidence for strong impact of somatization on the presentation of depressive symptoms and description of a patient subgroup with unfavorable clinical outcome.; Our results demonstrate the influence of a HTR2A polymorphism on aspects of somatization in major depression, which co-occurs with an unfavorable antidepressant treatment outcome. These results confirm and expand previous findings on somatization as a risk factor for treatment outcome in major depression.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Heck, Angela
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Nov 2017 08:01
Deposited On:30 Nov 2017 08:01

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