Stress regulation in multiple sclerosis: current issues and concepts

Heesen, C. and Mohr, D. C. and Huitinga, I. and Bergh, F. Then and Gaab, J. and Otte, C. and Gold, S. M.. (2007) Stress regulation in multiple sclerosis: current issues and concepts. Multiple Sclerosis Journal, 13 (2). pp. 143-148.

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Official URL: http://edoc.unibas.ch/46436/

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Since its first description by Charcot, psychological stress has been considered a triggering factor for exacerbations in multiple sclerosis, but until recently the clinical evidence for a causal relation was weak. Over the past years, a growing number of studies have started to elucidate this association and highlight potential mechanisms, including brain-immune communication. On 5 June 2005, a panel of international researchers discussed the current evidence. This article summarizes the observational, animal experimental, as well as human experimental findings on stress regulation in MS, as well as studies on the functioning of the major stress response systems, ie, the hypothalamo-pituitary-adrenal (HPA) axis and the autonomous nervous system (ANS) in MS. Consensus statements from the group to these aspects are given. Research objectives and strategies are delineated, as well as clinical implications.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Health & Intervention > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Gaab, Jens
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Sage Publications
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Nov 2017 07:34
Deposited On:28 Nov 2017 07:34

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