Directed mass spectrometry: towards hypothesis-driven proteomics

Schmidt, Alexander and Claassen, Manfred and Aebersold, Ruedi. (2009) Directed mass spectrometry: towards hypothesis-driven proteomics. Current Opinion in Chemical Biology, 13 (5-6). pp. 510-517.

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Official URL: http://edoc.unibas.ch/45913/

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To date, the vast majority of the proteomic data sets collected by mass spectrometry (MS) have been generated by nondirected methods, whereby the identified precursor ions are stochastically selected for sequencing from complex sample mixtures. Recently, new MS approaches have been developed in which the mass spectrometer is directed to select and fragment sets of precursor ions that represent the most informative peptides in a sample mixture. These directed MS methods have shown superior performance for the fast, sensitive, and highly reproducible generation of consistent data sets at low redundancy. In this manuscript we summarize recent technical advances in directed MS and discuss important applications to quantitative proteomics.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Proteomics (Schmidt)
UniBasel Contributors:Schmidt, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Nov 2017 09:09
Deposited On:29 Nov 2017 09:09

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