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Structural polymorphism of DNA-dendrimer complexes

Evans, H. M. and Ahmad, A. and Ewert, K. and Pfohl, T. and Martin-Herranz, A. and Bruinsma, R. F. and Safinya, C. R.. (2003) Structural polymorphism of DNA-dendrimer complexes. Physical Review Letters, 91 (7). 075501.

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Official URL: http://edoc.unibas.ch/45903/

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Abstract

DNA condensation in vivo relies on electrostatic complexation with small cations or large histones. We report a synchrotron x-ray study of the phase behavior of DNA complexed with synthetic cationic dendrimers of intermediate size and charge. We encounter unexpected structural transitions between columnar mesophases with in-plane square and hexagonal symmetries, as well as liquidlike disorder. The isoelectric point is a locus of structural instability. A simple model is proposed based on competing long-range electrostatic interactions and short-range entropic adhesion by counterion release.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Biophysikalische Chemie (Pfohl)
UniBasel Contributors:Pfohl, Thomas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physical Society
ISSN:0031-9007
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:19 Dec 2016 14:18
Deposited On:19 Dec 2016 14:18

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