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Exposure to ambient air pollution and the risk of inflammatory bowel disease : a european nested case-control study

Opstelten, Jorrit L. and Beelen, Rob M. J. and Leenders, Max and Hoek, Gerard and Brunekreef, Bert and van Schaik, Fiona D. M. and Siersema, Peter D. and Eriksen, Kirsten T. and Raaschou-Nielsen, Ole and Tjønneland, Anne and Overvad, Kim and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and de Hoogh, Kees and Key, Timothy J. and Luben, Robert and Chan, Simon S. M. and Hart, Andrew R. and Bueno-de-Mesquita, H. Bas and Oldenburg, Bas. (2016) Exposure to ambient air pollution and the risk of inflammatory bowel disease : a european nested case-control study. Digestive diseases and sciences, 61 (10). pp. 2963-2971.

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Official URL: http://edoc.unibas.ch/45282/

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Abstract

Industrialization has been linked to the etiology of inflammatory bowel disease (IBD).; We investigated the association between air pollution exposure and IBD.; The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) and ulcerative colitis (UC) (n = 104) and controls (n = 568) from Denmark, France, the Netherlands, and the UK, matched for center, gender, age, and date of recruitment. Air pollution data were obtained from the European Study of Cohorts for Air Pollution Effects. Residential exposure was assessed with land-use regression models for particulate matter with diameters of <10 μm (PM10), <2.5 μm (PM2.5), and between 2.5 and 10 μm (PMcoarse), soot (PM2.5 absorbance), nitrogen oxides, and two traffic indicators. Conditional logistic regression analyses were performed to calculate odds ratios (ORs) with 95 % confidence intervals (CIs).; Although air pollution was not significantly associated with CD or UC separately, the associations were mostly similar. Individuals with IBD were less likely to have higher exposure levels of PM2.5 and PM10, with ORs of 0.24 (95 % CI 0.07-0.81) per 5 μg/m(3) and 0.25 (95 % CI 0.08-0.78) per 10 μg/m(3), respectively. There was an inverse but nonsignificant association for PMcoarse. A higher nearby traffic load was positively associated with IBD [OR 1.60 (95 % CI 1.04-2.46) per 4,000,000 motor vehicles × m per day]. Other air pollutants were positively but not significantly associated with IBD.; Exposure to air pollution was not found to be consistently associated with IBD.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:de Hoogh, Kees
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer
ISSN:0163-2116
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:12 Dec 2016 14:10
Deposited On:12 Dec 2016 14:10

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