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Viral protein suppresses oxidative burst and salicylic acid-dependent autophagy and facilitates bacterial growth on virus-infected plants

Zvereva, Anna S. and Golyaev, Victor and Turco, Silvia and Gubaeva, Ekaterina G. and Rajeswaran, Rajendran and Schepetilnikov, Mikhail V. and Srour, Ola and Ryabova, Lyubov A. and Boller, Thomas and Pooggin, Mikhail M.. (2016) Viral protein suppresses oxidative burst and salicylic acid-dependent autophagy and facilitates bacterial growth on virus-infected plants. New Phytologis, 211 (3). pp. 1020-1034.

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Official URL: http://edoc.unibas.ch/45193/

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Abstract

Virus interactions with plant silencing and innate immunity pathways can potentially alter the susceptibility of virus-infected plants to secondary infections with nonviral pathogens. We found that Arabidopsis plants infected with Cauliflower mosaic virus (CaMV) or transgenic for CaMV silencing suppressor P6 exhibit increased susceptibility to Pseudomonas syringae pv. tomato (Pst) and allow robust growth of the Pst mutant hrcC-, which cannot deploy effectors to suppress innate immunity. The impaired antibacterial defense correlated with the suppressed oxidative burst, reduced accumulation of the defense hormone salicylic acid (SA) and diminished SA-dependent autophagy. The viral protein domain required for suppression of these plant defense responses is dispensable for silencing suppression but essential for binding and activation of the plant target-of-rapamycin (TOR) kinase which, in its active state, blocks cellular autophagy and promotes CaMV translation. Our findings imply that CaMV P6 is a versatile viral effector suppressing both silencing and innate immunity. P6-mediated suppression of oxidative burst and SA-dependent autophagy may predispose CaMV-infected plants to bacterial infection.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Ehemalige Einheiten Umweltwissenschaften > Pflanzenphysiologie Pathogenabwehr (Boller)
UniBasel Contributors:Boller, Thomas and Turco, Silvia and Golyaev, Victor
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley-Blackwell Publishing
ISSN:0028-646X
e-ISSN:1469-8137
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Oct 2017 13:28
Deposited On:25 Oct 2017 13:25

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