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Stress, glucocorticoids and memory: implications for treating fear-related disorders

de Quervain, Dominique and Schwabe, Lars and Roozendaal, Benno. (2016) Stress, glucocorticoids and memory: implications for treating fear-related disorders. Nature reviews. Neuroscience, 18 (1). pp. 7-19.

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Official URL: http://edoc.unibas.ch/45095/

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Abstract

Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing of emotionally arousing experiences. They enhance the consolidation of new memories, including those that extinguish older memories, but impair the retrieval of information stored in long-term memory. As strong aversive memories lie at the core of several fear-related disorders, including post-traumatic stress disorder and phobias, the memory-modulating properties of glucocorticoids have recently become of considerable translational interest. Clinical trials have provided the first evidence that glucocorticoid-based pharmacotherapies aimed at attenuating aversive memories might be helpful in the treatment of fear-related disorders. Here, we review important advances in the understanding of how glucocorticoids mediate stress effects on memory processes, and discuss the translational potential of these new conceptual insights.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
UniBasel Contributors:de Quervain, Dominique J.-F.
Item Type:Article, refereed
Publisher:Nature Publishing Group
ISSN:1471-003X
e-ISSN:1471-0048
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Sep 2018 16:54
Deposited On:04 Oct 2017 07:05

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