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Host-directed therapies for infectious diseases : current status, recent progress, and future prospects

Zumla, Alimuddin and Rao, Martin and Wallis, Robert S. and Kaufmann, Stefan H. E. and Rustomjee, Roxana and Mwaba, Peter and Vilaplana, Cris and Yeboah-Manu, Dorothy and Chakaya, Jeremiah and Ippolito, Giuseppe and Azhar, Esam and Hoelscher, Michael and Maeurer, Markus and Host-Directed Therapies Network consortium, . (2016) Host-directed therapies for infectious diseases : current status, recent progress, and future prospects. The Lancet infectious diseases, 16 (4). e47-e63.

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Official URL: http://edoc.unibas.ch/44526/

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Abstract

Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen-host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Gagneux, Sebastien and Reither, Klaus
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1473-3099
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Nov 2016 12:34
Deposited On:28 Nov 2016 12:34

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