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Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu

Sigg, Severin J. and Santini, Francesco and Najer, Adrian and Richard, Pascal U. and Meier, Wolfgang P. and Palivan, Cornelia G.. (2016) Nanoparticle-based highly sensitive MRI contrast agents with enhanced relaxivity in reductive milieu. Chemical Communications, 52 (64). pp. 9937-9940.

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Official URL: http://edoc.unibas.ch/44231/

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Abstract

Current magnetic resonance imaging (MRI) contrast agents often produce insufficient contrast for diagnosis of early disease stages, and do not sense their biochemical environments. Herein, we report a highly sensitive nanoparticle-based MRI probe with r(1) relaxivity up to 51.7 +/- 1.2 mM(-1) s(-1) (3T). Nanoparticles were co-assembled from Gd3+ complexed to heparin-poly(dimethylsiloxane) copolymer, and a reduction-sensitive amphiphilic peptide serving to induce responsiveness to environmental changes. The release of the peptide components leads to a r(1) relaxivity increase under reducing conditions and increases the MRI contrast. In addition, this MRI probe has several advantages, such as a low cellular uptake, no apparent cellular toxicity (tested up to 1mM Gd3+), absence of an anticoagulation property, and a high shelf stability (no increase in free Gd3+ over 7 months). Thus, this highly sensitive T-1 MRI contrast nanoparticle system represents a promising probe for early diagnosis through possible accumulation and contrast enhancement within reductive extracellular tumour tissue.
Faculties and Departments:05 Faculty of Science > Departement Chemie
05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
UniBasel Contributors:Meier, Wolfgang P.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:1359-7345
e-ISSN:1364-548X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:02 Jul 2019 08:12
Deposited On:28 Sep 2016 14:07

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