c-kit (CD117) expression in human tumors and its prognostic value: an immunohistochemical analysis

Medinger, Michael and Kleinschmidt, Manuela and Mross, Klaus and Wehmeyer, Barbara and Unger, Clemens and Schaefer, Hans-Eckart and Weber, Renate and Azemar, Marc. (2010) c-kit (CD117) expression in human tumors and its prognostic value: an immunohistochemical analysis. Pathology Oncology Research, 16 (3). pp. 295-301.

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Official URL: http://edoc.unibas.ch/43925/

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c-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types to their correlation with prognosis. Paraffin-embedded tumor tissues from 282 patients were analyzed immunohistochemically for c-kit expression. Survival and follow-up data were available from 192/282 (68%) patients. c-kit immunopositivity was found in 62/282 (22%) cases. c-kit expression was found in 14/83 (17%) colorectal cancers, in 13/62 (21%) breast cancers, in 7/20 sarcomas (35%), in 5/14 (36%) renal cell carcinomas, in 2/12 ovarian cancers (17%) and in 2/12 (17%) hepatocellular carcinomas. We found no significant correlation between c-kit expression and prognosis although a trend to a worse prognosis in patients with c-kit positive tumors could be observed. Expression of c-kit was found in tumor samples with varying intensities and infrequently.
Faculties and Departments:03 Faculty of Medicine
UniBasel Contributors:Medinger, Michael
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Verlag
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 10:00
Deposited On:04 Oct 2017 10:00

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