Medinger, Michael and Heim, Dominik and Gerull, Sabine and Halter, Jörg and Krenger, Werner and Buser, Andreas and Lengerke, Claudia and Bucher, Christoph and Passweg, Jakob. (2016) Increase of endothelial progenitor cells in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia. Leukemia Research, 47. pp. 22-25.
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Official URL: http://edoc.unibas.ch/43895/
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Abstract
Circulating endothelial progenitor cells (EPCs; CD31+ CD34(bright)CD133+ CD45(dim) cells) are novel markers of endothelial dysfunction and related to inflammatory processes such as acute graft-versus-host disease (aGvHD).; 47 patients with acute myeloid leukaemia (AML) who were in complete remission as they underwent allogeneic hematopoietic stem cell transplantation with myeloablative conditioning with PBSC as stem cell source were enrolled in the study. Blood samples for the quantitative analysis of circulating EPC levels were drawn at different time points in patients with and without aGvHD. CD34+ VEGFR2/KDR+ CD133+ triple-positive cells identified among CD34+ cells by FACS. EPC were quantified and data are presented as cells/ml whole blood.; Circulating EPC levels were not significantly different in patients with and without aGvHD prior to conditioning (baseline) and at the time of engraftment. However, at diagnosis of aGvHD≥grade 2, EPC levels increased whereas in patients without aGvHD the EPC levels remained significantly lower (3021±278 versus 2322±195 cells/ml; p>0.001). Patients with steroid-refractory aGvHD had high levels of EPC throughout. EPC levels fell in responding patients.; Our results demonstrate that the number of circulating EPCs is increased in patients with aGvHD compared to patients without aGvHD.
Faculties and Departments: | 03 Faculty of Medicine 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Hämatologie > Hämatologie (Passweg) |
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UniBasel Contributors: | Medinger, Michael and Buser, Andreas and Passweg, Jakob R. |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Elsevier |
ISSN: | 0145-2126 |
e-ISSN: | 1873-5835 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 09 Oct 2017 10:04 |
Deposited On: | 05 Jan 2017 09:08 |
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