Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease

Mistridis, Panagiota and Taylor, Kirsten I. and Kissler, Johanna M. and Monsch, Andreas U. and Kressig, Reto W. and Kivisaari, Sasa L.. (2014) Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease. Frontiers in human neuroscience, 7. p. 939.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/43890/

Downloads: Statistics Overview


Emotional information is typically better remembered than neutral content, and previous studies suggest that this effect is subserved particularly by the amygdala together with its interactions with the hippocampus. However, it is not known whether amygdala damage affects emotional memory performance at immediate and delayed recall, and whether its involvement is modulated by stimulus valence. Moreover, it is unclear to what extent more distributed neocortical regions involved in e.g., autobiographical memory, also contribute to emotional processing. We investigated these questions in a group of patients with Alzheimer's disease (AD), which affects the amygdala, hippocampus and neocortical regions. Healthy controls (n = 14), patients with AD (n = 15) and its putative prodrome amnestic mild cognitive impairment (n = 11) completed a memory task consisting of immediate and delayed free recall of a list of positive, negative and neutral words. Memory performance was related to brain integrity in region of interest and whole-brain voxel-based morphometry analyses. In the brain-behavioral analyses, the left amygdala volume predicted the immediate recall of both positive and negative material, whereas at delay, left and right amygdala volumes were associated with performance with positive and negative words, respectively. Whole-brain analyses revealed additional associations between left angular gyrus integrity and the immediate recall of positive words as well as between the orbitofrontal cortex and the delayed recall of negative words. These results indicate that emotional memory impairments in AD may be underpinned by damage to regions implicated in emotional processing as well as frontoparietal regions, which may exert their influence via autobiographical memories and organizational strategies.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie > Geriatrie (Kressig)
07 Faculty of Psychology > Departement Psychologie
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Neuroscience (Papassotiropoulos)
UniBasel Contributors:Monsch, Andreas U and Taylor, Kirsten and Mistridis, Panagiota and Kressig, Reto W.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Research Foundation
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:05 Jan 2017 08:10
Deposited On:05 Jan 2017 08:10

Repository Staff Only: item control page