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Gaining and sustaining schistosomiasis control : study protocol and baseline data prior to different treatment strategies in five African countries

Ezeamama, Amara E. and He, Chun-La and Shen, Ye and Yin, Xiao-Ping and Binder, Sue C. and Campbell, Carl H. and Rathbun, Stephen and Whalen, Christopher C. and N'Goran, Eliézer K. and Utzinger, Jürg and Olsen, Annette and Magnussen, Pascal and Kinung'hi, Safari and Fenwick, Alan and Phillips, Anna and Ferro, Josefo and Karanja, Diana M. S. and Mwinzi, Pauline N. M. and Montgomery, Susan and Secor, W. Evan and Hamidou, Amina and Garba, Amadou and King, Charles H. and Colley, Daniel G.. (2016) Gaining and sustaining schistosomiasis control : study protocol and baseline data prior to different treatment strategies in five African countries. BMC infectious diseases, 16. p. 229.

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Abstract

The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive chemotherapy (PCT) with praziquantel (PZQ)? This paper describes the process SCORE used to transform this question into a harmonized research protocol, the study design for answering this question, the village eligibility assessments and data resulting from the first year of the study.; Beginning in 2009, SCORE held a series of meetings to specify empirical questions and design studies related to different schedules of PCT for schistosomiasis control in communities with high (gaining control studies) and moderate (sustaining control studies) prevalence of Schistosoma infection among school-aged children. Seven studies are currently being implemented in five African countries. During the first year, villages were screened for eligibility, and data were collected on prevalence and intensity of infection prior to randomisation and the implementation of different schemes of PZQ intervention strategies.; These studies of different treatment schedules with PZQ will provide the most comprehensive data thus far on the optimal frequency and continuity of PCT for schistosomiasis infection and morbidity control.; We expect that the study outcomes will provide data for decision-making for country programme managers and a rich resource of information to the schistosomiasis research community.; The trials are registered at International Standard Randomised Controlled Trial registry (identifiers: ISRCTN99401114 , ISRCTN14849830 , ISRCTN16755535 , ISRCTN14117624 , ISRCTN95819193 and ISRCTN32045736 ).
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Health Impact Assessment (Utzinger)
UniBasel Contributors:Utzinger, Jürg and Garba, Amadou
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BioMed Central
ISSN:1471-2334
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:18 Oct 2016 10:50
Deposited On:31 Aug 2016 12:48

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