Midbrain circuits for defensive behaviour

Tovote, Philip and Esposito, Maria Soledad and Botta, Paolo and Chaudun, Fabrice and Fadok, Jonathan P. and Markovic, Milica and Wolff, Steffen B. E. and Ramakrishnan, Charu and Fenno, Lief and Deisseroth, Karl and Herry, Cyril and Arber, Silvia and Lüthi, Andreas. (2016) Midbrain circuits for defensive behaviour. Nature, 534 (7606). pp. 206-212.

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Official URL: http://edoc.unibas.ch/43573/

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Survival in threatening situations depends on the selection and rapid execution of an appropriate active or passive defensive response, yet the underlying brain circuitry is not understood. Here we use circuit-based optogenetic, in vivo and in vitro electrophysiological, and neuroanatomical tracing methods to define midbrain periaqueductal grey circuits for specific defensive behaviours. We identify an inhibitory pathway from the central nucleus of the amygdala to the ventrolateral periaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excitatory outputs to pre-motor targets in the magnocellular nucleus of the medulla. In addition, we provide evidence for anatomical and functional interaction of this freezing pathway with long-range and local circuits mediating flight. Our data define the neuronal circuitry underlying the execution of freezing, an evolutionarily conserved defensive behaviour, which is expressed by many species including fish, rodents and primates. In humans, dysregulation of this 'survival circuit' has been implicated in anxiety-related disorders.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Jan 2017 07:24
Deposited On:03 Jan 2017 07:24

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