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Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics

Gillingham, Dennis and Geigle, Stefanie and von Lilienfeld, O. Anatole. (2016) Properties and reactivity of nucleic acids relevant to epigenomics, transcriptomics, and therapeutics. Chemical Society Reviews, 45 (9). pp. 2637-2655.

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Official URL: http://edoc.unibas.ch/43413/

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Abstract

Developments in epigenomics, toxicology, and therapeutic nucleic acids all rely on a precise understanding of nucleic acid properties and chemical reactivity. In this review we discuss the properties and chemical reactivity of each nucleobase and attempt to provide some general principles for nucleic acid targeting or engineering. For adenine-thymine and guanine-cytosine base pairs, we review recent quantum chemical estimates of their Watson-Crick interaction energy, pi-pi stacking energies, as well as the nuclear quantum effects on tautomerism. Reactions that target nucleobases have been crucial in the development of new sequencing technologies and we believe further developments in nucleic acid chemistry will be required to deconstruct the enormously complex transcriptome.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Lilienfeld)
UniBasel Contributors:von Lilienfeld, Anatole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
ISSN:0306-0012
e-ISSN:1460-4744
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:23 Feb 2017 15:56
Deposited On:27 Jun 2016 13:22

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